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Endonuclease VIII$242.90Cat #: E078-B059A-0.08Learn More
Endonuclease VIII from E. coli has dual functions as an N-glycosylase and an AP-lyase. It removes damaged pyrimidines from double-stranded DNA to create an AP site. The AP-lyase activity then cleaves at this site, resulting in a 5′ phosphate and a 3′ phosphate. This enzyme targets damaged bases like thymine glycol and uracil glycol. Unlike Endonuclease III, which only has β lyase activity, Endonuclease VIII also exhibits δ lyase activity, enabling it to address a broader range of DNA damage.
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Products
Alphazyme is focused on the rapid development and customization of enzymes consumed by commercial “nucleic acid literacy” platforms. The following enzymes are available for evaluation testing, customization, or scale-up to meet specific requirements.
All Alphazyme enzymes are:
• Ready for customization (formulation, process tuning, QC specifications, fill sizes, and reaction buffers)
• Designed for scale-up
• Fully traceable within our ISO 13485:2016 compliant electronic Quality System
• BSE/TSE-compliant
• Available in REACH compliant formulations
Codex® enzyme products, developed by Codexis and manufactured by Alphazyme, offer specific performance improvements across various genomic applications.
Alphazyme continually develops new enzymes and we welcome the opportunity to produce an enzyme specifically for your needs.
Please contact us at Sales@alpha-zyme.com to discuss your specific needs, or to request samples.
For more information about Alphazyme enzymes, please click here.